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Key Documents

SML1008

Sigma-Aldrich

C527

≥98% (HPLC)

Synonym(s):

2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione

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About This Item

Empirical Formula (Hill Notation):
C17H8FNO3
CAS Number:
Molecular Weight:
293.25
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: 0.3 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H

InChI key

ULJDFEYQOPCCPM-UHFFFAOYSA-N

Biochem/physiol Actions

C527 is a potent inhibitor of the deubiquitinating enzyme complex USP1/UAF1 (IC50 = 0.88 μM). C527 dose dependently inhibits USP1 activity and induced proteasomal degradation of the trasnscriptional regulator ID1 in U20S osteosarcoma cells.
C527 is a potent inhibitor of the deubiquitinating enzyme complex USP1/UAF1.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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