SML0957

KRN633

≥98% (HPLC)

• Synonym(s): KRN-633, N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N′-propyl-urea
• Empirical Formula (Hill Notation): C₂₀H₂₁ClN₄O₄
• CAS Number: 286370-15-8
• Molecular Weight: 416.86
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 3 mg/mL, clear (warmed)
• storage temp.: −20°C
• InChI: 1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
• InChI key: VPBYZLCHOKSGRX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of VEGFR.

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC₅₀ values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC₅₀ = 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC₅₀ >/= 10 μM).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable