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Key Documents

SML0946

Sigma-Aldrich

Lacidipine

≥98% (HPLC)

Synonym(s):

3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester, CID 5311217, GR-43659X, GX-1048

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10 MG
$77.60
50 MG
$250.00

About This Item

Empirical Formula (Hill Notation):
C26H33NO6
CAS Number:
103890-78-4
Molecular Weight:
455.54
UNSPSC Code:
12352106
NACRES:
NA.77

$77.60

Available to ship onApril 29, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N1C(=C(C(C(=C1C)C(=O)OCC)c2c(cccc2)\C=C\C(=O)OC(C)(C)C)C(=O)OCC)C

InChI

1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+

InChI key

GKQPCPXONLDCMU-CCEZHUSRSA-N

Biochem/physiol Actions

Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension.
Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000321252
034M4727V

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A Dasgupta et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 29(2), 239-243 (2009-12-17)
The cardiovascular drug lacidipine (Lc) is known to possess antibacterial activity. Further potentiation of action is possible by synergism between Lc and an antibiotic or a non-antibiotic. The minimum inhibitory concentration (MIC) of antibiotics, Lc and other non-antibiotics were detected
Yasin Bayir et al.
Cardiovascular toxicology, 12(2), 166-174 (2012-02-10)
In this study, the effects of lacidipine (LAC), ramipril (RAM), and valsartan (VAL) on biochemical and histopathologic changes in heart tissue were studied in rats with isoproterenol-induced (ISO-induced) myocardial infarction (MI). LAC, RAM, and VAL had been administered via oral
Ileana Lulić et al.
Lijecnicki vjesnik, 133(3-4), 98-100 (2011-05-27)
The sense of smell plays an important role in the maintenance of a good quality of life. Disturbances of olfactory sense include complete or partial loss of smell, distortion of smell, and perceived smell in the absence of real stimuli.
Janardhan Singh et al.
Archives of physiology and biochemistry, 117(1), 12-17 (2010-11-26)
The present study was planned to evaluate the effects of lacidipine on STZ induced diabetic neuropathy. Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, motor nerve conduction velocity (MNCV), nociception and histopathology of tibial
Asish Dasgupta et al.
The Indian journal of medical research, 135(6), 913-916 (2012-07-25)
Vibrio cholerae produces acute infection by liberating potent enterotoxin, called cholera toxin in human intestine. Cardiovascular drug lacidipine possessing powerful in vitro action against V. cholerae was tested to determine its possible activity against a toxigenic V. cholerae strain in
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