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Key Documents

SML0891

Sigma-Aldrich

L-152,804

≥98% (HPLC)

Synonym(s):

5,5-Dimethyl-2-(2,3,4,9-tetrahydro-­3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexane­dione, 5,5-Mmethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3 cyclohexanedione, 9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone, L-152804, L152804

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About This Item

Empirical Formula (Hill Notation):
C23H26O4
CAS Number:
6508-43-6
Molecular Weight:
366.45
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19,24H,9-12H2,1-4H3/t19-/m0/s1

InChI key

CCJIUBMPDVWYLU-IBGZPJMESA-N

Biochem/physiol Actions

L-152,804 is a potent and selective non-peptide neuropeptide Y Y5 receptor antagonist.
L-152,804 is a potent and selective non-peptide neuropeptide Y Y5 receptor antagonist. L-152,804 induces a potent reduction of food intake in rodents.

Features and Benefits

This compound is featured on the Neuropeptide Y Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
113M4612V

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M C R Gumbs et al.
Neuroscience, 447, 28-40 (2019-12-31)
The preclinical multicomponent free-choice high-fat high-sucrose (fcHFHS) diet has strong validity to model diet-induced obesity (DIO) and associated maladaptive molecular changes in the central nervous system. fcHFHS-induced obese rats demonstrate increased sensitivity to intracerebroventricular infusion of the orexigenic Neuropeptide Y
Shiba Yousefvand et al.
Canadian journal of physiology and pharmacology, 96(12), 1301-1307 (2018-10-17)
Neuropeptide Y (NPY) plays a mediatory role in cerebral insulin function by maintaining energy balance. The current study was designed to determine the role of insulin in food intake and its interaction with NPY receptors in 8 experiments using broiler

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