SML0890

SB 452533

≥98% (HPLC)

• Synonym(s): N-(2-Bromophenyl)-N′-[2-[ethyl(3-methylphenyl)amino]ethyl]urea, SB-452533
• Empirical Formula (Hill Notation): C₁₈H₂₂BrN₃O
• CAS Number: 459429-39-1
• Molecular Weight: 376.29
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• InChI: 1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
• InChI key: IFJYEGJUQIBBQV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor with a pKb of 7.7 versus capsaicin and pIC₅₀ of 7.0 versus pH. At higher concentrations, SB-452533 is also active at TRPM8 with an IC₅₀ of 571 nM. It has a high clearance rate, so is not suitable for in vivo use.

SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor.

Features and Benefits

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Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H410
• pcodes: P273 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable