SML0880

Shz-1

≥98% (HPLC)

• Synonym(s): 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide benzenesulfonic acid
• Empirical Formula (Hill Notation): C₁₃H₁₁BrN₂O₃S
• CAS Number: 326886-05-9
• Molecular Weight: 355.21
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• Storage temp.: −20°C
• InChI: 1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+
• Inchi Key: OEMCLQLAWYKPRK-OQLLNIDSSA-N

Description

Biochem/physiol Actions

Shz-1 is an enhancer of myocardial regenerative repair by stem cells. Shz-1 specifically activates Nkx2.5, one of the earliest lineage-restricted genes to be expressed in cardiovascular progenitor cells and improves iPSC-derived cardiac differentiation. Shz-pretreated human mobilized peripheral blood mononuclear cells (PBMCs) injected in a rodent model of myocardial infarction enhanced engraftment of the cells and improved cardiac function.

Shz-1 is an enhancer of myocardial regenerative repair by stem cells; specifically activates Nkx2.5, and improves iPSC-derived cardiac differentiation.

The members of sulfonyl-hydrazone family are known to induce differentiation in cardiomyocytes.

Features and Benefits

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Safety Information

• Pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable