SML0871
NeuroSensor 521
≥98% (HPLC)
Synonym(s):
7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin
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About This Item
Empirical Formula (Hill Notation):
C21H21NO4
CAS Number:
Molecular Weight:
351.40
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow to orange
solubility
DMSO: 10 mg/mL, clear
shipped in
dry ice
storage temp.
−70°C
Biochem/physiol Actions
NeuroSensor 521 is a fluorescent turn-on sensor designed for the selective visualization of norepinephrine over epinephrine in fixed and live cells and the fluorescence is not affected by fixation. NeuroSensor 521 binds to all primary amines, but binds catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine. Because of the spectral properties of NeuroSensor 521, the unbound and bound states can be monitored using 440 and 488 nm excitation, respectively. In chromaffin cells NeuroSensor 521 stained the norepinephrine-containing cells preferentially over epinephrine-containing cells under identical conditions.
NeuroSensor 521 is a fluorescent turn-on sensor designed for the selective visualization of norepinephrine over epinephrine in fixed and live cells.
Other Notes
Light sensitive and air sensitive
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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