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Key Documents

SML0869

Sigma-Aldrich

Phox-l2

≥98% (HPLC)

Synonym(s):

3a,4,5,9b-Tetrahydro-8-nitro-4-(3-nitrophenyl)-3H-cyclopenta[c]quinoline

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About This Item

Empirical Formula (Hill Notation):
C18H15N3O4
CAS Number:
Molecular Weight:
337.33
UNSPSC Code:
12352200

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Phox-I2 is a NOX2 inhibitor.
Phox-I2 is an inhibitor of the NADPH oxidase enzyme complex (NOX2) activation that binds to p67phox and abolishes Rac1 binding. Phox-I2 inhibits NOX2-mediated superoxide production in human and murine neutrophils without detectable toxicity.

pictograms

Exclamation mark

signalword

Warning

pcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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