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Key Documents

SML0859

Sigma-Aldrich

WDR5-0103

≥98% (HPLC)

Synonym(s):

3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-benzoic acid methyl ester, Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate

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About This Item

Empirical Formula (Hill Notation):
C21H25N3O4
CAS Number:
Molecular Weight:
383.44
UNSPSC Code:
12352200

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

WDR5-0103 is a WD40-repeat antagonist that binds to WDR55 central cavity. WDR5-0103 inhibits MLL1 histone methyltransferase activity in vitro through disruption of the interaction of MLL with WDR5.
WDR5-0103 is a WD40-repeat antagonist.

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jimsheena V Karakkat et al.
Nucleic acids research, 47(19), 10086-10103 (2019-09-19)
The metabolic sensor Per-Arnt-Sim (Pas) domain-containing serine/threonine kinase (PASK) is expressed predominantly in the cytoplasm of different cell types, although a small percentage is also expressed in the nucleus. Herein, we show that the nuclear PASK associates with the mammalian

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