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SML0821

Sigma-Aldrich

UCD38B hydrochloride

≥98% (HPLC)

Synonym(s):

5’-Benzylglycinyl-amiloride, N-[6-Amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine phenylmethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H16ClN7O3 · xHCl
CAS Number:
1115177-19-9
Molecular Weight:
377.79 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825604
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC(NC(C(N=C1Cl)=C(N)N=C1CNC(OCC2=CC=CC=C2)=O)=O)=N.[H]Cl

InChI

1S/C15H16ClN7O3.ClH/c16-11-9(21-12(17)10(22-11)13(24)23-14(18)19)6-20-15(25)26-7-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H2,17,21)(H,20,25)(H4,18,19,23,24);1H

InChI key

SFHYWDNJBRFZKW-UHFFFAOYSA-N

Biochem/physiol Actions

UCD38B is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator) that is cytotoxic to proliferating and non-proliferating glioma cell lines. UCD38B induces caspase-independent necrosis in U87 glioma MDA231 breast cancer cells. It appears that the necrotic pathway is mediated by AIF (apoptotic inducible factor).

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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