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Key Documents

SML0779

Sigma-Aldrich

RSVA314

≥98% (HPLC)

Synonym(s):

2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide

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About This Item

Empirical Formula (Hill Notation):
C18H21N3O3
CAS Number:
316130-82-2
Molecular Weight:
327.38
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

light orange

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

RSVA314 is a resveratrol analog that is a potent indirect activator of AMPK (AMP-activated protein kinase).
RSVA314 is a resveratrol analog that is a potent indirect activator of AMPK (AMP-activated protein kinase). RSVA314 is a potent inhibitor of adipogenesis in vitro in cultured cells and in vivo in mice. Apparently RSVA314 activates AMPK via a mechanism implicating CaMKKβ and LKB1. Also RSVA314 increases intracellular clearance of the amyloidogenic peptide Aβ, the core component of the amyloid plaques.

Features and Benefits

This compound is featured on the AMPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
073M4622V

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Articles

AMPKs

The AMP-activated protein kinase (AMPK) acts as a sensor of cellular energy status. AMPK exists as heterotrimeric complexes comprising a catalytic α subunit and regulatory β and γ subunits.

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