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SML0727

Sigma-Aldrich

cisTPD

≥98% (HPLC)

Synonym(s):

(2a,4a,6a)-2,4,6-Triphenyl-1,3-dioxane, (4R,6S)-rel-2,4,6-Triphenyl-1,3-dioxane

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About This Item

Empirical Formula (Hill Notation):
C22H20O2
CAS Number:
59825-01-3
Molecular Weight:
316.39
UNSPSC Code:
51111800
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

cisTPD is a constitutive androstane receptor (CAR) agonist that inhibits FOXO1 and HNF4 driven expression of the gluconeogeneis PEPCK and glucose-6-phosphatase. cisTPD reduces blood glucose levels, insulin sensitivity and weight gain in rats fed a high fat diet.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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