SML0695
LH846
≥98% (HPLC)
Synonym(s):
N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide
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About This Item
Empirical Formula (Hill Notation):
C16H13ClN2OS
CAS Number:
Molecular Weight:
316.81
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
InChI
1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
InChI key
DYHAMRNAHTWYKY-UHFFFAOYSA-N
Biochem/physiol Actions
LH846 is a potent and selective inhibitor of the known clock regulatory kinase Casein Kinase CK1δ, with an IC50 of 290 nm, compared to an IC50 of 2.5 μm for CKIα , 1.3 μm for CKIε, and minimal effect on CK2 and 50 other kinases tested. Circadian rhythym has been studied for a long time for things such as jet lag rhythym related disorders, but more recently it has beencome apparent that clock dysfunction can contribute to a variety of pathologies including circadian sleep disorders, cardiovascular disease, cancer, and metabolic disease, so studies of clock regulating enzymes have increased. LH846 increased circadian period by 10 hours in human U2OS cells.
LH846 is a potent and selective inhibitor of the known clock regulatory kinase Casein Kinase CK1δ.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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