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Key Documents

SML0677

Sigma-Aldrich

IWP12

≥98% (HPLC)

Synonym(s):

IWP-12, N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

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About This Item

Empirical Formula (Hill Notation):
C18H18N4O2S3
CAS Number:
688353-45-9
Molecular Weight:
418.56
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)

InChI key

RBFDSBJDWZOTGR-UHFFFAOYSA-N

Biochem/physiol Actions

IWP (inhibitor of Wnt production) inhibitors are known to prevent Wnt protein generation. Abnormal Wnt signalling associated with tumorigenesis and metastasis of tumors.[1]
IWP12 is Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn), which is suitable for in vivo assays. IWP12 blocked post resection juvenile zebrafish tailfin regeneration.
IWP12 is Wnt inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
033M4624V

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The development of highly potent inhibitors for porcupine.
Wang X, et al.
Journal of Medicinal Chemistry, 56(6), 2700-2704 (2013)

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