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SML0674

Sigma-Aldrich

Ramosetron hydrochloride

≥98% (HPLC)

Synonym(s):

(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060

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10 MG
$94.20
50 MG
$364.00

About This Item

Empirical Formula (Hill Notation):
C17H17N3O · HCl
CAS Number:
132907-72-3
Molecular Weight:
315.80
UNSPSC Code:
12352200
NACRES:
NA.77

$94.20

Available to ship onMay 02, 2025Details

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assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -36 to -46°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C

InChI

1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChI key

XIXYTCLDXQRHJO-RFVHGSKJSA-N

Biochem/physiol Actions

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative,[1] containing an indole ring.[2] It inhibits colon contraction mediated by serotonin, competitively.[1]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000266264
0000370844
0000370844
0000266264
0000247049

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Hyo-Jin Byon et al.
European journal of anaesthesiology, 29(4), 192-196 (2012-01-26)
Postoperative nausea and vomiting remains a clinically important problem after strabismus surgery in children. To study the benefit of adding midazolam to ramosetron on the incidence of postoperative nausea, retching or vomiting and on the incidence of postoperative agitation. A
In Jun Koh et al.
Clinical orthopaedics and related research, 470(6), 1718-1727 (2011-12-14)
Current pain management protocols involving many anesthetic and analgesic drugs reportedly provide adequate analgesia after TKA. However, control of emetic events associated with the drugs used in current multimodal pain management remains challenging. We determined (1) whether ramosetron prophylaxis reduces
Jung-Hee Ryu et al.
International journal of surgery (London, England), 11(2), 183-187 (2013-01-15)
Up to 75% of the patients undergoing laparoscopic cholecystectomy develop postoperative nausea and vomiting (PONV). Both ramosetron, a serotonin subtype 3 (5-HT3) antagonist, and dexamethasone are effective for PONV prophylaxis following laparoscopic cholecystectomy but their combined effect has not been
Youn Yi Jo et al.
Surgical endoscopy, 26(8), 2306-2311 (2012-02-24)
In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. One hundred twenty female
Takahiro Mihara et al.
Anesthesia and analgesia, 117(2), 329-339 (2013-06-13)
Ramosetron has been shown to have a very strong effect for preventing postoperative nausea and vomiting (PONV) in previous meta-analyses. However, these previous meta-analyses included a number of studies by Fujii et al. which have now been proven to have
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