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SML0665

Sigma-Aldrich

LY-456236

≥98% (HPLC)

Synonym(s):

(4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride, 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride, LY456236, MPMQ

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About This Item

Empirical Formula (Hill Notation):
C16H15N3O2 · HCl
CAS Number:
338736-46-2
Molecular Weight:
317.77
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16;/h3-10H,1-2H3,(H,17,18,19);1H

InChI key

AVKFOWUSTVWZQN-UHFFFAOYSA-N

Biochem/physiol Actions

LY-456236 is a selective mGlu1 receptor antagonist with an IC50 value of 143 nM for mGlu1 compared to > 10 μM for mGlu5 receptors.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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