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Key Documents

SML0659

Sigma-Aldrich

LYG-202

≥98% (HPLC)

Synonym(s):

5-Hydroxy-8-methoxy-7-[4-(4-methyl-1-piperazinyl)butoxy]-2-phenyl-4H-1-benzopyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C25H30N2O5
CAS Number:
1175077-25-4
Molecular Weight:
438.52
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

LYG-202 is a synthetic flavanoid that induces apoptosis and is a CK2 inhibitor.
LYG-202 is a synthetic flavanoid that induces apoptosis in several cancer cell lines. LYG-202 induces G1/S phase cell cycle arrest and apoptosis in HCT116 cells by a mechanism that involves increases in p21(WAF1/Cip1) and Rb expression. In HepG2 cells, the compound LYG-202 potentiates the apoptotic effects of TNFα by inhibiting casein kinase 2 (CK2).

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
073M4736V

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Faiza M Kalfalah et al.
Cell cycle (Georgetown, Tex.), 14(11), 1704-1715 (2015-04-16)
To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes

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