SML0626

RFRP-3 human trifluoroacetate salt

≥98% (HPLC)

• Synonym(s): NPVF, Neuropeptide VF (124-131), RFamide-related peptide-3
• Empirical Formula (Hill Notation): C₄₅H₇₂N₁₄O₁₀ · xC₂HF₃O₂
• CAS Number: 311309-27-0
• Molecular Weight: 969.14 (free base basis)
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
• InChI key: JFZCLMZUABKABL-GVCDGELBSA-N

Description

Amino Acid Sequence

Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2

Biochem/physiol Actions

RFRP-3 (RFamide-related peptide-3) is a homolog of avian gonadotropin-inhibitory hormone. RFRP-3 binds to the GPR147 receptor (also known as neuropeptide FF receptor 1). RFRP-3 blocks release of gonadotropin from the pituitary, and inhibits FSH-, LH- and forskolin-stimulated cAMP accumulation and progesterone production in human granulosa-lutein cells.

RFRP-3 is a homolog of avian gonadotropin-inhibitory hormone. RFRP-3 binds to the GPR147 receptor (also known as neuropeptide FF receptor 1).

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable