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Key Documents

SML0605

Sigma-Aldrich

IQ-1S

≥98% (HPLC)

Synonym(s):

11H-Indeno[1,2-b]quinoxalin-11-one oxime Sodium; IQ-1 sodium

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About This Item

Empirical Formula (Hill Notation):
C15H8N3O · Na
CAS Number:
23146-22-7
Molecular Weight:
269.23
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

IQ-1S is an inhibitor of JNK kinases, with a preference for JNK3.
IQ-1S is an inhibitor of JNK kinases, with a preference for JNK3. Kd values for IQ-3 binding to JNK 1, 2 and 3 binding are 390, 360 and 87 nM, respectively. The compound inhibits JNK phosphorylation and NFkB /AP-1 transcriptional activity in human monocytic cells at low mM concentrations, and inhibits CD4+ T-cell immune response in a murine delayed-type hypersensitivity (DTH) model.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
043M4618V

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Articles

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

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