SML0600

LPSF/GQ-02

≥98% (HPLC)

• Synonym(s): (5Z)-5-[(4-Chlorophenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione, 5-(4-Chloro-benzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione, GQ-02
• Empirical Formula (Hill Notation): C₁₈H₁₄ClNO₂S
• CAS Number: 870554-60-2
• Molecular Weight: 343.83
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

LPSF/GQ-02 is a new thiazolidinedione that shows improved insulin resistance, reduces the area of atherosclerotic lesions, and offers a protective effect for the endothelium in LDL receptor-deficient mice.

LPSF/GQ-02 is a new thiazolidinedione that shows improved insulin resistance, reduces the area of atherosclerotic lesions, and offers a protective effect for the endothelium in LDL receptor-deficient mice. LPSF/GQ-02 induced an overexpression of eNOS and significantly inhibited the expression of metalloproteinases, both of which can result in anti-inflammatory effects.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H319,H410
• pcodes: P273 - P305 + P351 + P338 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable