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SML0513

Sigma-Aldrich

SKF83822 hydrobromide

Synonym(s):

6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propen-1-yl)-1H-3-Benzazepine-7,8-diol hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C20H22ClNO2 · HBr
CAS Number:
74115-10-9
Molecular Weight:
424.76
MDL number:
MFCD07773055
UNSPSC Code:
12352200
PubChem Substance ID:
329825522
NACRES:
NA.77

storage temp.

2-8°C

SMILES string

Br.Cc1cccc(c1)C2CN(CCc3c(Cl)c(O)c(O)cc23)CC=C

InChI

1S/C20H22ClNO2.BrH/c1-3-8-22-9-7-15-16(11-18(23)20(24)19(15)21)17(12-22)14-6-4-5-13(2)10-14;/h3-6,10-11,17,23-24H,1,7-9,12H2,2H3;1H

InChI key

CFWPKYBBXBANLU-UHFFFAOYSA-N

Biochem/physiol Actions

SKF83822 is a dopamine receptor agonist that only activates the D1 monomers and stimulates adenylate cyclase, but not PI hydrolysis.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H400

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Yuji Odagaki et al.
Journal of receptor and signal transduction research, 39(1), 9-17 (2019-06-22)
Although multiple roles of dopamine through D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors are initiated primarily through stimulation or inhibition of adenylyl cyclase via Gs/olf or Gi/o, respectively, there have been many reports indicating diverse signaling

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