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SML0498

Sigma-Aldrich

PNU112455A

≥98% (HPLC)

Synonym(s):

4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H11N5O2S · HCl
CAS Number:
21886-12-4
Molecular Weight:
301.75
MDL number:
MFCD00023272
UNSPSC Code:
12352200
PubChem Substance ID:
329825447
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1

InChI

1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17;/h1-6H,(H2,12,16,17)(H3,11,13,14,15);1H

InChI key

XBXQRCJKDCEQBS-UHFFFAOYSA-N

Biochem/physiol Actions

PNU112455A is a CDK 2/5 inhibitor.
PNU112455A is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cyclin-dependent Kinases (CDKs)

Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).

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