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SML0469

Sigma-Aldrich

Poloxin

≥98% (HPLC)

Synonym(s):

2-Methyl-5-(1-methylethyl)-1-[O-(2-methylbenzoyl)oxime]-2,5-Cyclohexadiene-1,4-dione

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About This Item

Empirical Formula (Hill Notation):
C18H19NO3
CAS Number:
321688-88-4
Molecular Weight:
297.35
MDL number:
MFCD00534351
UNSPSC Code:
12352200
PubChem Substance ID:
329825426

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

CC(C)C1=CC(=NOC(=O)c2ccccc2C)C(C)=CC1=O

InChI

1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3

InChI key

CMOJHDQJJPIVEC-UHFFFAOYSA-N

Biochem/physiol Actions

Poloxin is a non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor that targets the polo-box domain. Poloxin inductees Plk1 mislocalization, chromosome congression defects, mitotic arrest, and apoptosis in HeLa cells.
Poloxin is a non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
092M4723V

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Tae Gi Kim et al.
Biological & pharmaceutical bulletin, 40(9), 1454-1462 (2017-09-05)
Although enzyme-linked immunosorbent assay (ELISA) technology has been widely accepted for binding assays against the polo-box domain (PBD) of polo-like kinase-1 (Plk1), these assays have a limitation-related heterogeneous procedure, such as multiple incubations and washing steps to apply high-throughput screenings
Andreas Ritter et al.
Oncotarget, 7(51), 84271-84285 (2016-10-08)
Polo-like kinase 1 (Plk1) has been established as one of the most promising targets for molecular anticancer intervention. In fact, various Plk1 inhibitors have been identified and characterized. While the data derived from the bench are prospective, the clinical outcomes
Yoshiya Adachi et al.
Oncotarget, 8(45), 78452-78465 (2017-11-08)
Volasertib, a selective PLK1 inhibitor, was effective for acute myeloid leukemia (AML) patients in clinical trials. However, its efficacy was limited in mono-therapy, and a higher incidence of fatal events was revealed in the combination with low-dose cytarabine. Thus, optimization
Christian Schenk et al.
Journal of virology, 92(24) (2018-09-28)
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein with key functions in regulating viral RNA replication and assembly. Two phosphoisoforms are discriminated by their different apparent molecular weights: a basally phosphorylated (p56) and a hyperphosphorylated (p58) variant.
Andreas Ritter et al.
Oncotarget, 6(33), 34475-34493 (2015-10-07)
Adipose-derived stem cells are capable of differentiating into multiple cell types and thus considered useful for regenerative medicine. However, this differentiation feature seems to be associated with tumor initiation and metastasis raising safety concerns, which requires further investigation. In this

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