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SML0456

Sigma-Aldrich

HBB2

≥98% (HPLC)

Synonym(s):

(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one

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About This Item

Empirical Formula (Hill Notation):
C17H14O3
CAS Number:
131359-24-5
Molecular Weight:
266.29
MDL number:
MFCD01790784
UNSPSC Code:
12352202
PubChem Substance ID:
329824735
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

Oc1ccccc1\C=C\C(=O)\C=C\c2ccccc2O

InChI

1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+

InChI key

YNVAHBUBGBLIEY-WGDLNXRISA-N

Biochem/physiol Actions

HBB2 is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. Also, HBB2 upregulates Hsp70 in an HSF1-dependent manner. It appears that HBB2 reacts with cysteine residues of KEAP1, which leads to activation of NRF2, and binds to Hsp90 Cys that leads to activation of HST1.
HBB2 is an inducer of the KEAP1/NRF2/ARE pathway, and upregulator of Hsp70.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
082M4627V

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