SML0441
LUF6283
≥95% (HPLC)
Synonym(s):
5-Butyl-1H-Pyrazole-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C8H12N2O2
CAS Number:
Molecular Weight:
168.19
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution; warmed)
Storage temp.
2-8°C
SMILES string
CCCCc1cc(n[nH]1)C(O)=O
InChI
1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
Inchi Key
ZJTXSGLJNBAMJS-UHFFFAOYSA-N
Biochem/physiol Actions
LUF6283 is a GPR109A (HCA2) partial agonist.
LUF6283 is a partial agonist of the hydroxy-carboxylic acid receptor 2 (HCA2; GPR109A). LUF6283 binds HCA2 with a Ki value of 0.55 mM, and an intrinsic efficacy for agonist activity of 76% of the full agonist effect of niacin. The EC50 values for niacin and LUF6283 are 0.41 and 3.1 mM, respectively. LUF6283 effectively lowers plasma lipid levels, but does not induce cutaneous flushing as observed with niacin treatment.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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