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Key Documents

SML0405

Sigma-Aldrich

JF5 hydrochloride

≥98% (HPLC)

Synonym(s):

1,2,3,4-Tetrahydro-4-pentyl-9H-cyclopenta[b]quinolin-9-imine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H22N2 · HCl
CAS Number:
Molecular Weight:
290.83
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Cl.CCCCCN1C2=C(CCC2)C(=N)c3ccccc13

InChI

1S/C17H22N2.ClH/c1-2-3-6-12-19-15-10-5-4-8-13(15)17(18)14-9-7-11-16(14)19;/h4-5,8,10,18H,2-3,6-7,9,11-12H2,1H3;1H

InChI key

GNYIHGOBDNSDIW-UHFFFAOYSA-N

Biochem/physiol Actions

JF5 is an allosteric inhibitor of PAR1.
JF5 is an allosteric inhibitor of PAR1. The molecule binds to helix 8 of the receptor, directly interfering with receptor coupling to Gαq, but not Gα12. JF5 also inhibits α2A-adrenergic receptor and mPAR4 activity, but not hPAR4. JF5 blocks granule secretion from platelets activated with the PAR1 agonist SFLLRN (IC50 4 μM), but does not affect platelet activation by convulxin (GPVI agonist), PMA or A23187.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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