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SML0381

Sigma-Aldrich

ALLO-1

≥98% (HPLC)

Synonym(s):

3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione

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About This Item

Empirical Formula (Hill Notation):
C17H15ClN2O2
CAS Number:
37468-32-9
Molecular Weight:
314.77
MDL number:
MFCD19441284
UNSPSC Code:
51111800
PubChem Substance ID:
329825381

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC1N(Cc2ccccc2)C(=O)N(C1=O)c3ccc(Cl)cc3

InChI

1S/C17H15ClN2O2/c1-12-16(21)20(15-9-7-14(18)8-10-15)17(22)19(12)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3

InChI key

GHAJNZREWTZYQJ-UHFFFAOYSA-N

Biochem/physiol Actions

ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Miyuki Sato et al.
Nature cell biology, 20(1), 81-91 (2017-12-20)
In Caenorhabditis elegans embryos, paternally provided organelles, including mitochondria, are eliminated by a process of selective autophagy called allophagy, the mechanism by which mitochondrial DNA is inherited maternally. However, it remains unclear how paternal organelles are recognized and targeted for

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