SML0379
Nodinitib-1
≥98% (HPLC)
Synonym(s):
1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130
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5 MG
$95.20
25 MG
$538.00
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5 MG
$95.20
25 MG
$538.00
About This Item
Empirical Formula (Hill Notation):
C14H13N3O2S
CAS Number:
Molecular Weight:
287.34
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2
InChI
1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChI key
SRFABRWQVPCPRG-UHFFFAOYSA-N
Biochem/physiol Actions
Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.
Nodinitib-1 is a selective inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Miao Wang et al.
Journal of neuroinflammation, 17(1), 364-364 (2020-12-03)
Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported to
Aram Lee et al.
Journal of ginseng research, 44(2), 300-307 (2020-03-10)
Emerging evidence suggests that endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction due to persistent inflammation is a key component and emerging concept in the pathogenesis of vascular diseases. Ginsenoside Rg3 (Rg3), an active compound from red ginseng, has been known to
Yi-Hsin Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(48), E7818-E7827 (2016-11-20)
Induction of nucleotide-binding oligomerization domain 2 (NOD2) and downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2) by human cytomegalovirus (HCMV) is known to up-regulate antiviral responses and suppress virus replication. We investigated the role of nucleotide-binding oligomerization domain 1 (NOD1), which also
Myra G Dela Pena-Ponce et al.
PloS one, 12(8), e0183324-e0183324 (2017-08-17)
Epidemiologic studies have reported an inverse relationship between childhood Helicobacter pylori infection and development of allergic asthma. Because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that H. pylori may directly influence airway epithelial cell innate
Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells.
Jiarui Bi et al.
Scientific reports, 7(1), 4411-4411 (2017-07-02)
Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflammation by activating the anti-inflammatory cytokine transforming growth factor-β1
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