SML0318

Alvameline tartrate

≥97% (HPLC)

• Synonym(s): 2-Ethyl-5-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-2H-tetrazole tartrate, 5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate, Lu 25-109; 3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl-pyridine tartrate
• Empirical Formula (Hill Notation): C₉H₁₅N₅ · xC₄H₆O₆
• Molecular Weight: 193.25 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825323
• NACRES: NA.77

Properties

• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O[C@@H]([C@H](O)C(O)=O)C(O)=O.CCn1nnc(n1)C2=CCCN(C)C2
• InChI: 1S/C9H15N5.C4H6O6/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-1(3(7)8)2(6)4(9)10/h5H,3-4,6-7H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.0/s1
• InChI key: JHGFYOXAUPXDGA-WUUYCOTASA-N

Description

Biochem/physiol Actions

Alvameline (Lu 25-109) is a muscarinic M1 receptor agonist and M2/M3 receptor antagonist that was under investigation for the treatment of Alzheimer′s disease. Alvameline (Lu 25-109) improved cognitive function following traumatic brain injury (TBI) in rats, but failed to show significant positive results in clinical trials.

Alvameline is a muscarinic M1 receptor agonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable