SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• Synonym(s): Tyr-Aib-Trp-Phe trifluoroacetate salt
• Empirical Formula (Hill Notation): C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• CAS Number: 1334763-90-4
• Molecular Weight: 599.68 (free base basis)
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825306
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: lyophilized solid
• color: white to beige
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
• InChI key: NELSAMPJZPTPEG-MDQBHWJISA-N

Description

Biochem/physiol Actions

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable