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SML0185

Sigma-Aldrich

NQDI-1

≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C19H13NO4
CAS Number:
175026-96-7
Molecular Weight:
319.31
MDL number:
MFCD03265970
UNSPSC Code:
12352200
PubChem Substance ID:
329825214
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: ≥5 mg/mL (warmed to 60° C)

storage temp.

2-8°C

SMILES string

CCOC(=O)C1=C2c3ccccc3C(=O)c4cccc(NC1=O)c24

InChI

1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)

InChI key

UFJGFNHRMPMALC-UHFFFAOYSA-N

Application

NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages.

Biochem/physiol Actions

NQDI-1 inhibits the activation of caspase-3 and prevents cell death by apoptosis. It is neuroprotective and prevents the ROS-induced apoptosis of the neurons.
NQDI-1 is an inhibitor of apoptosis signal-regulating kinase (ASK1), Ki = 500 nM. NQDI-1 shows little or no inhibitory activity against Aurora A or ROCK kinases, or several receptor tyrosine kinases.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inflammation is implicated in ischemic stroke and is involved in abnormal homeostasis. Activation of the immune system leads to breakdown of the blood-brain barrier and, thereby, infiltration of immune cells into the brain. Upon cerebral ischemia, infiltrated macrophages and microglia
Koji Nomura et al.
Neuroscience letters, 549, 163-167 (2013-06-08)
Reactive oxygen species (ROS) are believed to be involved in many forms of neurodegeneration, including ischaemic infarct damage and Alzheimer's disease. Despite the known involvement of p38 and JNK MAP kinases in mediating apoptosis and cell death in a variety
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International journal of cancer, 146(7), 1963-1978 (2019-08-08)
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Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

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