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SML0175

Sigma-Aldrich

Pyrovalerone hydrochloride

≥98% (HPLC)

Synonym(s):

1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride, Centroton, F 1983, Sp 1059, Thymergix

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About This Item

Empirical Formula (Hill Notation):
C16H23NO·HCl
CAS Number:
1147-62-2
Molecular Weight:
281.82
EC Number:
214-556-9
UNSPSC Code:
41116107
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

drug control

psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

color

off-white to light brown

solubility

H2O: ≥5 mg/mL at 60 °C

storage temp.

2-8°C

InChI

1S/C16H23NO.ClH/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14;/h7-10,15H,3-6,11-12H2,1-2H3;1H

InChI key

MWRACNBZNVAJHE-UHFFFAOYSA-N

Application

Pyrovalerone hydrochloride may be used in dopamine-mediated cell signaling studies.

Biochem/physiol Actions

Pyrovalerone hydrochloride is a CNS Stimulant; norepinephrine-dopamine reuptake inhibitor (NDRI)
Pyrovalerone hydrochloride is a rapidly-absorbed psychostimulant. It belongs to the class of synthetic cathinones often used as performance-enhancing agent by athletes before being banned.[1][2]
Pyrovalerone is a norepinephrine-dopamine reuptake inhibitor (NDRI) that acts as a CNS stimulant.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000078251
0000078252
101M4620V

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Sabina Strano-Rossi et al.
Rapid communications in mass spectrometry : RCM, 24(18), 2706-2714 (2010-09-04)
A method for the toxicological screening of the new designer drug methylenedioxypyrovalerone (MDPV) is described; with an emphasis on its application for anti-doping analysis. The metabolism of MDPV was evaluated in vitro using human liver microsomes and S9 cellular fractions
The metabolism of pyrovalerone hydrochloride.
W Michaelis et al.
Journal of medicinal chemistry, 13(3), 497-503 (1970-05-01)
H S Shin et al.
Journal of analytical toxicology, 20(7), 568-572 (1996-11-01)
Detection and identification of pyrovalerone and its metabolite, a hydroxylated product, are described. Their identities were confirmed by comparing their mass spectra and gas chromatographic retention times with those of the synthetic standards. The analytical method of pyrovalerone and its
D S Lho et al.
Journal of chromatography. B, Biomedical applications, 687(1), 253-259 (1996-12-06)
Pyrovalerone and its hydroxylated metabolite have been identified by gas chromatography-mass spectrometry in rat urine and plasma. A sensitive gas chromatographic method for the quantitative analysis of pyrovalerone in rat urine and plasma is described. The method also permits the
C Héron et al.
European journal of pharmacology, 264(3), 391-398 (1994-11-03)
We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such as mazindol, pyrovalerone, nomifensine and methylphenidate
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