SML0109

GLYX-13 trifluoroacetate

≥98% (HPLC)

• Synonym(s): L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate; Thr-Pro-Pro-Thr-NH2 trifluoroacetate, Rapastinel, TPPT-amide trifluoroacetate
• Empirical Formula (Hill Notation): C₁₈H₃₁N₅O₆ · xC₂HF₃O₂
• CAS Number: 117928-94-6
• Molecular Weight: 413.47 (free base basis)
• MDL number: MFCD20527320
• UNSPSC Code: 12352209
• PubChem Substance ID: 329825164
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H]([C@@H](C)O)C(N)=O
• InChI: 1S/C18H31N5O6.C2HF3O2/c1-9(24)13(19)18(29)23-8-4-6-12(23)17(28)22-7-3-5-11(22)16(27)21-14(10(2)25)15(20)26;3-2(4,5)1(6)7/h9-14,24-25H,3-8,19H2,1-2H3,(H2,20,26)(H,21,27);(H,6,7)/t9-,10-,11+,12+,13+,14+;/m1./s1
• InChI key: BCWVNVCGYWOAAK-GDLIIDCZSA-N

Description

Application

GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.[1]

Biochem/physiol Actions

GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.

GLYX-13 trifluoroacetate is a bain penetrable positive allosteric modulator of NMDA receptor acting via the glycine site; cognitive enhancer in learning models

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable