SML0095

Conessine

≥97% (HPLC)

• Synonym(s): (3β)-N,N-dimethyl-con-5-enin-3-amine, Conessin, NSC 119994, Neriine, Roquessine, Wrightine
• Empirical Formula (Hill Notation): C₂₄H₄₀N₂
• CAS Number: 546-06-5
• Molecular Weight: 356.59
• EC Number: 208-897-2
• MDL number: MFCD00016752
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825153
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to tan
• solubility: ethanol: ≥2 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
• InChI: 1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
• InChI key: GPLGAQQQNWMVMM-MYAJQUOBSA-N

Description

General description

Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.[1]

Biochem/physiol Actions

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H₃ receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H₃ over H₄ and does not bind to H₁ or H₂ receptors. The molecule also binds to the human α₂C₄ adrenergic receptor (pKi = 7.98).

H3 receptor antagonist

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable