SMB00603
Cholesteryl Ester Transfer Protein (rCETP) human
recombinant, expressed in CHO cells, Supplied by Roar Biomedical, Inc.
Synonym(s):
CETP
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.26
recombinant
expressed in CHO cells
concentration
≥20 μg/mL (rCETP protein)
500-900 μg/mL (total protein)
storage temp.
−70°C
General description
Cholesteryl ester transfer protein (CETP) is a hydrophobic glycoprotein. It is released mostly from the liver. CETP is present in normal human plasma. The CETP gene is mapped to human chromosome 16q13. It has 16 exons, that spans around 25 kb. The mature CETP consists of four N-linked sugars with a variable glycosylation site.
Biochem/physiol Actions
Cholesteryl ester transfer protein (CETP) transfers neutral lipids from high-density lipoproteins (HDL) to very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway. Recombinant CETP is partially purified from CHO cells overexpressing the full-length human protein. This recombinant protein is active, and is useful as a source of CETP for mass or activity assays, high-throughput screening, or for performing structure-activity relationship (SAR) studies on inhibitor compounds.
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Description
Pricing
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Gerard Vassiliou et al.
Journal of lipid research, 45(9), 1683-1693 (2004-07-03)
Previous reports attributed cholesteryl ester transfer protein (CETP)-mediated HDL cholesteryl ester (CE) selective uptake to the CETP-mediated transfer of CE from HDL to newly secreted apolipoprotein B-containing lipoproteins, which are then internalized by the LDL receptor (LDL-R). CETP has also
CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis
Tatiana Martins Venancio, et al.
Mediators of Inflammation, 10, 1155-1155 (2016)
Plasma cholesteryl ester transfer protein (CETP) in relation to human pathophysiology
The HDL Handbook, 35-59 (2010)
Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
Barter P J, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 23(2), 160-167 (2003)
Hiroshi Okamoto et al.
Clinica chimica acta; international journal of clinical chemistry, 375(1-2), 92-98 (2006-07-25)
Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma. Human plasma was incubated with or without
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