The product was lyophilized from a mixture of water and acetonitrile containing 0.1 % trifluoroacetic acid (the solvent used to purify the product by reverse-phase chromatography).
SCP0094
Caspase Inhibitor
Synonym(s):
Ac-AEVD-CHO, caspase 6 inhibitor, caspase 8 inhibitor
Sign Into View Organizational & Contract Pricing
Select a Size
5 MG
$301.00
$301.00
Usually ships in 2 weeks.
Notify Me
Get notified when this item is ready to ship via email.
All Photos(1)
Select a Size
Change View
5 MG
$301.00
About This Item
Empirical Formula (Hill Notation):
C19H30N4O9
Molecular Weight:
458.46
UNSPSC Code:
12352200
NACRES:
NA.32
$301.00
Usually ships in 2 weeks.
Notify Me
Get notified when this item is ready to ship via email.
Recommended Products
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
Storage temp.
−20°C
Gene Information
human ... CASP10(843) , CASP6(839) , CASP8(841) , CASP9(842)
Amino Acid Sequence
Ac-Ala-Glu-Val-Asp-al
General description
Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.[1]
Application
Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.[2]
Biochem/physiol Actions
The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Triterpene saponosides from Lysimachia ciliata differentially attenuate invasive potential of prostate cancer cells
Koczurkiewicz P, et al.
Chemico-Biological Interactions, 206(1), 6-17 (2013)
Basic Concepts of Molecular Pathology, 32-32 (2009)
Alessandra De Leo et al.
PLoS pathogens, 13(8), e1006596-e1006596 (2017-08-31)
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a human gammaherpesvirus recognized as the principal causative agent of KS and primary effusion lymphoma (PEL). KSHV establishes persistent latent infection in B lymphocytes where viral gene expression is restricted, in part, by a
-
In what type of buffer is the lyophilisate resuspended?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
