SAE0006
Thrombin human
recombinant, expressed in HEK 293 cells, aqueous solution, ≥95% (SDS-PAGE)
Synonym(s):
Factor IIa
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About This Item
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
recombinant
expressed in HEK 293 cells
product line
BioUltra
assay
≥95% (SDS-PAGE)
form
aqueous solution
specific activity
≥1500 units/mg protein
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... F2(2147)
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General description
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects. Thrombin is also known as coagulation factor IIa.[1] It is a serine endopeptidase that hydrolyzes peptide and ester bonds specifically at the carboxylic side of arginine.[2] This enzyme converts fibrinogen to fibrin.[3]
Application
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess in vitro hemostatic properties of French lyophilized plasma.†
Physical form
supplied as a solution in 20 mM MES, pH 6.0, 500 mM choline chloride
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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