SAB5700564

Anti-Phospho-FADD-S194 antibody produced in rabbit

• Synonym(s): FADD, GIG3, MORT1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 23
• species reactivity: human
• concentration: 3.67 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: Q13158
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer194)
• Gene Information: human ... FADD(8772)

Description

General description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Immunogen

A phospho synthetic peptide corresponding to residues surrounding S194 of human FADD.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable