SAB5700475

Anti-Phospho-LAT-Y171 antibody produced in rabbit

• Synonym(s): IMD52, LAT, LAT1, pp36
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 24; 27; 28
• species reactivity: human
• concentration: 1.95 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: O43561
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr171)
• Gene Information: human ... LAT(27040)

Description

General description

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen

A synthetic phosphorylated peptide around Y171 of human LAT (NP_001014987.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable