SAB5700453

Anti-Phospho-CBL-Y700 antibody produced in rabbit

• Synonym(s): C-CBL, CBL, CBL2, FRA11B, NSLL, RNF55, c-Cbl
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 99
• species reactivity: human
• concentration: 0.30 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P22681
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr700)
• Gene Information: human ... CBL(867)

Description

General description

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5′ UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Immunogen

A synthetic phosphorylated peptide around Y700 of human CBL (NP_005179.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable