Histone H3/ histone cluster 1 H3 family member a (HIST1H3A) is a core member of the histone family. HIST1H3A is encoded by the gene mapped to human chromosome 6p22.2. The encoded protein is composed of ~136 amino acids.
Specificity
This antibody reacts to Histone H3 monomethylated at Lysine 18 (K18me1). No cross reactivity with dimethylated Lysine 18 (K18me2) or trimethylated Lysine 18(K18me3), or other methylations in histone H3.
Immunogen
Synthetic peptide corresponding to Monomethyl-Histone H3 (Lys18)
Biochem/physiol Actions
Histones acts as structural scaffolds for DNA packaging. Histone H3 plays an important role in replication and DNA repair. Histone H3 is heavily post-translationally modified than the other members of histone family. Mutations in the gene leads to cerebellar high-grade gliomas. Phosphorylated histone H3 is implicated in the modulation of gene expression and in chromosome condensation/segregation. Monomethyl-histone H3 acts as a potent epigenetic mark for repressed euchromatin in Chlamydomonas.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Histone H3 phosphorylation: Universal code or lineage specific dialects
Cerutti H, et al.
Epigenetics, 4(2), 71-75 (2009)
Monomethyl Histone H3 Lysine 4 as an Epigenetic Mark for Silenced Euchromatin in Chlamydomonas
Van DK, et al.
Plant Cell, 17(9), 2439-2453 (2005)
Histone H3 K27M mutations in adult cerebellar high-grade gliomas.
Nakata S, et al.
Brain Tumor Pathology, 34(3), 113-119 (2017)
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Sadakierska-Chudy A
Neurotoxicity Research, 27(1), 84-97 (2015)
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
