SAB5500170

Anti-PU.1 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP238, affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• recombinant: expressed in proprietary host
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: SP238, monoclonal
• species reactivity: human (tested)
• species reactivity (predicted by homology): pig, rat, mouse
• technique(s): immunohistochemistry: 1:100
• isotype: IgG
• UniProt accession no.: P17947
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... SPI1(6688)

Description

General description

PU.1 is a transcription factor of the Ets family and activates target genes through the purine-rich PU-box. PU.1 plays an important role for the differentiation of myeloid cells and early B cell lymphocytes. PU.1 is overexpressed in some B cell lymphoma, Hodgkin, and non- Hodgkin lymphoma.

Spi-1 proto-oncogene (SPI1), also known as PU.1, is a mammalian transcription factor. It is encoded by the gene mapped to human chromosome 11p11.2. The encoded protein belongs to the E26 transformation specific (Ets) family of transcription factors. SPI1 is characterized with a C-terminal domain, an N-terminal transactivation domain and a central PEST domain involved in protein-protein interaction. The protein is mainly expressed in cells of the hematopoietic lineage such as macrophages, granulocytes and B lymphocytes.

Immunogen

Synthetic peptide derived from the internal region of the human PU.1 protein.

Biochem/physiol Actions

Spi-1 proto-oncogene (SPI1)/ PU.1 plays an essential role in myeloid development. It also acts as a transcription activator and is involved in macrophage proliferation. In addition, PU.1 along with other transcription factors, plays a vital role in fetal hematopoiesis. PU.1 controls cellular communication in the immune system. Thus, loss/reduced gene expression leads to loss of cellular communication, which in turn is associated with the development of leukemia.

Features and Benefits

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Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable