SAB5500142
Anti-MCM2 antibody, Rabbit monoclonal
clone SP85, recombinant, expressed in proprietary host, affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP85, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
frog, bovine, mouse, rat, dog
technique(s)
flow cytometry: 1:100
immunoblotting: 1:100
immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... MCM2(4171)
General description
Mini chromosome maintenance protein 2 (MCM2) is a human nuclear protein. This cell-cycle regulatory protein is similar to members of the family of early S-phase proteins and is expressed in four phases of the cell cycle. MCM2 gene is mapped to human chromosome 3q21.3. MCM2 protein is a member of eukaryal MCM2–7 subunits and is expressed in the nucleus and cytoplasm of various tissues.
Immunogen
Synthetic peptide derived from internal region of human MCM2 protein.
Biochem/physiol Actions
Mini chromosome maintenance protein 2 (MCM2) is involved in regulating DNA replication, is crucial in the cell cycle. From its localization, CDCL1 is a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML). MCM-2 levels are elevated in salivary gland tumors and malignant lesions of the oral cavity. It serves as a marker for the detection of oral squamous cell carcinoma (OSCC). MCM2 overexpression also displays pro-apoptotic and apoptotic. MCM2 is also implicated in nonsyndromic hearing loss.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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François-Xavier Nouhaud et al.
Clinical genitourinary cancer, 16(4), e795-e805 (2018-03-20)
Gene copy number variations (CNVs) have been reported to be frequent in renal cell carcinoma (RCC), with potential prognostic value for some. However, their clinical utility, especially to guide treatment of metastatic disease remains to be established. Our objectives were
A Mincheva et al.
Cytogenetics and cell genetics, 65(4), 276-277 (1994-01-01)
BM28, a newly recognized human nuclear protein, possibly plays an important role in two crucial steps of the cell cycle e.g. the onset of DNA replication and cell division. It shows significant similarity to members of a recently defined family
Petra Mlcochova et al.
The EMBO journal, 37(1), 50-62 (2017-11-01)
We report that DNA damage induced by topoisomerase inhibitors, including etoposide (ETO), results in a potent block to HIV-1 infection in human monocyte-derived macrophages (MDM). SAMHD1 suppresses viral reverse transcription (RT) through depletion of cellular dNTPs but is naturally switched
Seyed Mohammad Razavi et al.
The Malaysian journal of pathology, 37(3), 253-258 (2015-12-30)
Proteins necessary for DNA replication and normal regulation for the cell cycle include minichromosome maintenance-2 (Mcm-2). Overexpression of this protein in several premalignant and malignant lesions has been observed. In this study, the diagnostic value of Mcm-2 expression in distinguishing
Petra Mlcochova et al.
The EMBO journal, 36(5), 604-616 (2017-01-27)
An unresolved question is how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle-associated proteins including MCM2 and cyclins A, E, D1/D3 in macrophages, without evidence for
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