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Key Documents

COO/COA

SAB5300011

Monoclonal Anti-THPO antibody produced in mouse

Name: Monoclonal Anti-THPO antibody produced in mouse
Brand: SIGMA

clone 1B11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

MGDF, MKCSF, ML, MPLLG, TPO

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B11, monoclonal

form

buffered aqueous solution

mol wt

37.8 kDa

species reactivity

human

technique(s)

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
western blot: 1:500-1:2,000

isotype

IgG2a

NCBI accession no.

NM_000460.2

UniProt accession no.

P40225

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... THPO(7066)

General description

Thrombopoietin (TPO) is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It is an acidic glycoprotein. The gene encoding it is localized on human chromosome 3q27.1.

Immunogen

Purified recombinant fragment of human THPO expressed in E.coli.
Mouse monoclonal antibody raised against THPO

Biochem/physiol Actions

Thrombopoietin (TPO) stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the cellular proto-oncogene (c-mpl) receptor and acts as an important regulator of circulating platelets. High levels of TPO have been observed in patients with aplastic anemia.

Physical form

Purified antibody in PBS with 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

PM12083128

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The molecular mechanisms that control thrombopoiesis.

Kaushansky K

The Journal of Clinical Investigation, 115(12), 3339-3347 (2005)

Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.

Majed J Dasouki et al.

Blood, 122(20), 3440-3449 (2013-10-03)

We recently identified 2 siblings afflicted with idiopathic, autosomal recessive aplastic anemia. Whole-exome sequencing identified a novel homozygous missense mutation in thrombopoietin (THPO, c.112C>T) in both affected siblings. This mutation encodes an arginine to cysteine substitution at residue 38 or

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