Olfactomedin 1 (OLFM1) is localized to various organs like the heart, lungs and eyes. The gene encoding it is localized on human chromosome 9q34.3.
Specificity
Detects ~70 kDa (Pancortin-1, Pancortin-3) and ~20 kDa (Pancortin-2 and Pancortin-4).
Immunogen
Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS), Accession Number Q99784.
Biochem/physiol Actions
Olfactomedin 1 (OLFM1) is downregulated in the human endometrium. When it is upregulated, complications like endometriosis and ectopic pregnancy are observed. OLFM1 may act as a cell adhesion protein and it has been shown to modulate the Wnt-signaling pathway.
Features and Benefits
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Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Laboratory investigation; a journal of technical methods and pathology, 92(2), 256-264 (2011-10-05)
Ectopic pregnancy (EP) occurs when the embryo fails to transit to the uterus and attach to the luminal epithelium of the Fallopian tube (FT). Tubal EP is a common gynecological emergency and more than 95% of EP occurs in the
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