Contactin-1 (CNTN1) is a neural cell adhesion molecule which is part of the immunoglobulin gene family. It is highly expressed in gastric cancers and the gene encoding it is localized on human chromosome 12q11–q12.
Specificity
Deteects ~120 kDa.
Immunogen
Synthetic peptide amino acids 21-37 (D/EFTWHRRYGHGVSEEDKC) extracellular domain of rat contactin, Accession Number A57112.
Biochem/physiol Actions
Contactin-1 (CNTN1) functions in the development of the nervous system and aids in tumor growth. It takes part in different biochemical pathways and interacts with many proteins like receptor protein tyrosine phosphatase-β (RPTP-β). In the nervous system, it also regulates interactions between proteins on the cell surface .
Features and Benefits
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Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Contactin-1 (CNTN-1), a glycosyl phosphatidylinositol anchor neural cell adhesion molecule (ACAM), is thought to function not only in nervous system development but also in the invasion and metastasis of several tumours. To investigate whether CNTN-1 is involved in multidrug resistance
Journal of cancer research and clinical oncology, 141(12), 2109-2120 (2015-05-09)
Contactin-1 (CNTN-1) has been shown to promote cancer metastasis. Previously, we have reported that the expression of CNTN-1 was upregulated in gastric cancer tissues compared with adjacent normal tissues. Here, we investigated the significance of CNTN-1 expression and its underlying
Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto-immune response directed against myelin sheaths of the optic nerve. Here, we demonstrate in two frequently used
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