SAB5200018

Monoclonal Anti-PCLO antibody produced in mouse

clone 6H9-B6, 1 mg/mL, purified immunoglobulin

• Synonym(s): Anti-ACZ, Anti-Aczonin, Anti-PCLO, Anti-PICO, Anti-Piccolo, 6H9-B6, Anti-presynaptic cytomatrix protein antibody
• UNSPSC Code: 12352203

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 6H9-B6, monoclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen predicted mol wt 550 kDa
• species reactivity: rat, human
• concentration: 1 mg/mL
• technique(s): indirect ELISA: suitable; western blot: suitable
• isotype: IgG2bκ
• NCBI accession no.: NP_001104266.1
• UniProt accession no.: Q9Y6V0
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Pclo(26875)

Description

General description

PCLO (presynaptic cytomatrix protein) gene codes for a protein called piccolo. The encoded protein is a component of the presynaptic active zone.

Specificity

No cross-reactivity to Bassoon, band at ~550 kDa correspondng to the molecular weight of Piccolo.

Immunogen

Full length protein, Accession Number BC001304.1

Biochem/physiol Actions

PCLO (presynaptic cytomatrix protein) gene might be associated with the risk of major depression disorder and bipolar disorder. Mutation in PCLO gene results in pontocerebellar hypoplasia. PCLO serves as a biomarker type 2 diabetes. It controls presynaptic monoamine production. Piccolo plays an important role in synaptic transmission. It mediates the process of docking, vesicle priming and retrieval. Piccolo is involved in neurotransmission and functions at ribbon synapses. Loss of piccolo causes synapse degeneration due to the breakdown of many presynaptic proteins. It regulates ubiquitination, F-actin assembling and proteostasis which helps in maintaining synaptic integrity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable