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SAB5100005

Sigma-Aldrich

Imprint® ChIP-Validated Monoclonal Anti-POU5F1 (Oct4) antibody produced in mouse

clone PF-29, purified immunoglobulin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PF-29, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ChIP: suitable
western blot: suitable

isotype

IgG2a

UniProt accession no.

Q01860

shipped in

dry ice

Storage temp.

−20°C

Gene Information

human ... POU5F1(5460)

General description

POU class 5 homeobox 1 (POU5F1), also known as OCT-3, OCT-4, and OCT 3/4, is encoded by the gene mapped to human chromosome 6p21.33. This octamer‐binding protein is expressed in adult human stem cells, immortalized nontumorigenic cells, and tumor cells and cell lines. POU5F1 belongs to the POU family of transcription factors.

Application

Imprint® ChIP-Validated Monoclonal Anti-POU5F1 (Oct4) antibody produced in mouse has been used in chromatin immune precipitation experiment.

Biochem/physiol Actions

POU class 5 homeobox 1 (POU5F1) regulates pluripotency in mammalian cells. In addition, it also acts as a reprogramming factor and aids in the derivation of induced pluripotent stem (iPS) cells. POU5F1 gene mutation causes lung adenocarcinoma.

Quality

ChIP Validation:

View ChIP Validation Data for lot number: 082M4798

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Legal Information

Imprint is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
082M4798

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Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis
Mo XB, et al.
Journal of Neurology, 266(11), 2699-2709 (2019)
Potentially functional polymorphisms in POU5F1 gene are associated with the risk of lung cancer in Han Chinese
Niu R, et al.
BioMed Research International, 2015(11), 2699-2709 (2015)
On the origin of POU5F1
Frankenberg S and Renfree MB
BMC biology, 11(1), 1-12 (2013)
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors
Looijenga LHJ, et al.
Cancer research, 63(9), 2244-2250 (2003)
Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells
Kapetanou, et al.
Free Radical Biology & Medicine, 103, 226-235 (2017)
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