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Key Documents

SAB5100004

Sigma-Aldrich

Imprint® ChIP-Validated Monoclonal Anti-p53 (BP53-12) antibody produced in mouse

clone BP53-12, ascites fluid, isotype IgG2a

Synonym(s):

Imprint® Monocolonal Anti-p53 antibody produced in mouse, Anti-LFS1, Anti-P53, Anti-TP53, Anti-TRP53, Anti-tumor protein p53

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BP53-12, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ChIP: suitable
western blot: suitable

isotype

IgG2a

shipped in

dry ice

storage temp.

−20°C

General description

The tumor protein p53 (p53) gene is a tumor suppressor gene that encodes p53 protein.[1] p53 protein is expressed in the nucleus and directly binds to the DNA.[2] This protein is a nuclear transcription factor. It is made up of three operative domains like the NH2-terminal acidic transactivation domain, DNA-binding domain and a COOH-terminal oligomerization domain.[3] The TP53 gene is located on the human chromosome at 17p13.1.[4]

Biochem/physiol Actions

p53 protein is necessary for protecting the fidelity of DNA from several factors by initiating cell-cycle-arrest, DNA repair and apoptosis as a response to cellular stress.[5][1][6] It is a part of many biological events such as senescence, immune response, cell differentiation and angiogenesis.[1] p53 protein is also involved in autophagy, regulating metabolism and oxidative status of the cell.[5] Mutations in the TP53 gene are associated with several types of cancer like leukemia, sarcomas, brain, breast cancers and adrenal cortical carcinomas.[2]

Quality

ChIP Validation:

View ChIP Validation Data for lot number: 032M4764

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Legal Information

Imprint is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
032M4764

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Multiple myeloma involving central nervous system: high frequency of chromosome 17p13. 1 (p53) deletions
Chang H, et al.
British Journal of Haematology, 127(3), 280-284 (2018)
Role of p53 in cell death and human cancers
Ozaki T and Nakagawara A
Cancers, 3(1), 994-1013 (2011)
Recent advances in p53 research and cancer treatment
Suzuki K and Matsubara H
Journal of Biomedicine and Biotechnology, 2011(15), 2527-2532 (2011)
TP53 mutations and SNPs as prognostic and predictive factors in patients with breast cancer
Huszno J and Grzybowska E
Oncology Letters, 16(1), 34-40 (2018)
New therapeutic strategies to treat human cancers expressing mutant p53 proteins
Blandino G and Di Agostino S
Journal of Experimental & Clinical Cancer Research, 37(1), 1-13 (2018)
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