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Key Documents

SAB5100003

Sigma-Aldrich

Imprint® ChIP-Validated Monoclonal Anti-p53 (PAb1801) antibody produced in mouse

clone PAb1801, isotype IgG1, purified immunoglobulin

Synonym(s):

Imprint® Monocolonal Anti-p53 antibody produced in mouse, Anti-LFS1, Anti-P53, Anti-TP53, Anti-TRP53, Anti-tumor protein p53

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About This Item

UNSPSC Code:
12352200

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PAb1801, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ChIP: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P04637

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TP53(7157)

General description

Tumor protein p53, also called as guardian of the genome, is encoded by the gene mapped to human chromosome 17p13.1.[1] p53 is a sequence-specific transcription factor[2] containing transactivation domain, proline-rich domain, specific DNA-binding domain (DBD) and a tetramerization domain. In addition, it also contains a nonspecific DNA-binding domain that might be involved in DNA damage recognition.[3]

Biochem/physiol Actions

Tumor protein p53 prevents tumor progression through transcriptional regulation of targeted genes involved in cell cycle arrest, DNA repair, apoptosis and cell senescence.[2] Mutation in the gene leads to the development of various types of human cancers including liver fluke-associated cholangiocarcinoma (CCA).[2] p53 also cause Li-Fraumeni syndrome (LFS) in its mutated form.[1]

Quality

ChIP Validation:

View ChIP Validation Data for lot number: 032M4762

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Legal Information

Imprint is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
032M4763

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Evaluation of p53 and Its Target Gene Expression as Potential Biomarkers of Cholangiocarcinoma in Thai Patients
Puetkasichonpasutha J, et al.
Asian Pacific Journal of Cancer Prevention, 21(3), 791-798 (2020)
The UMD TP53 database and website: update and revisions
Hamroun D, et al.
Human Mutation, 27(1), 14-20 (2006)
A common molecular mechanism underlies two phenotypically distinct 17p13. 1 microdeletion syndromes
Shlien A, et al.
American Journal of Human Genetics, 87(5), 631-642 (2010)

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